spacer
spacer

PDBsum entry 2a4d

Go to PDB code: 
protein links
Ligase PDB id
2a4d
Jmol
Contents
Protein chain
139 a.a. *
Waters ×69
* Residue conservation analysis
PDB id:
2a4d
Name: Ligase
Title: Structure of the human ubiquitin-conjugating enzyme e2 varia 1)
Structure: Ubiquitin-conjugating enzyme e2 variant 1. Chain: a. Fragment: catalytic domain, residues 82-220. Synonym: uev-1, croc-1, ubiquitin-conjugating enzyme varian traf6-regulated ikk activator 1 beta uev1a, p/okcl.19. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ube2v1, croc1, ube2v, uev1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Biol. unit: Dimer (from PQS)
Resolution:
1.69Å     R-factor:   0.185     R-free:   0.240
Authors: J.R.Walker,G.V.Avvakumov,S.Xue,E.M.Newman,F.Mackenzie,J.Weig M.Sundstrom,C.Arrowsmith,A.Edwards,A.Bochkarev,S.Dhe-Pagano Structural Genomics Consortium (Sgc)
Key ref: Y.Sheng et al. (2012). A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. Mol Cell Proteomics, 11, 329-341. PubMed id: 22496338 DOI: 10.1074/mcp.O111.013706
Date:
28-Jun-05     Release date:   12-Jul-05    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q13404  (UB2V1_HUMAN) -  Ubiquitin-conjugating enzyme E2 variant 1
Seq:
Struc:
147 a.a.
139 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     UBC13-UEV1A complex   8 terms 
  Biological process     nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway   24 terms 
  Biochemical function     protein binding     7 terms  

 

 
DOI no: 10.1074/mcp.O111.013706 Mol Cell Proteomics 11:329-341 (2012)
PubMed id: 22496338  
 
 
A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
Y.Sheng, J.H.Hong, R.Doherty, T.Srikumar, J.Shloush, G.V.Avvakumov, J.R.Walker, S.Xue, D.Neculai, J.W.Wan, S.K.Kim, C.H.Arrowsmith, B.Raught, S.Dhe-Paganon.
 
  ABSTRACT  
 
No abstract given.