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PDBsum entry 244d

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DNA PDB id
244d
Jmol
Contents
DNA/RNA
Metals
_CA ×9
_NA ×14
Waters ×514

References listed in PDB file
Key reference
Title The high-Resolution crystal structure of a parallel-Stranded guanine tetraplex.
Authors G.Laughlan, A.I.Murchie, D.G.Norman, M.H.Moore, P.C.Moody, D.M.Lilley, B.Luisi.
Ref. Science, 1994, 265, 520-524. [DOI no: 10.1126/science.8036494]
PubMed id 8036494
Abstract
Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG4T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.
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