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UniProt functional annotation for Q56185 | ||
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| UniProt code: Q56185. |
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| Organism: | |
Streptomyces wedmorensis. |
| Taxonomy: | |
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces. |
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| Function: | |
Non-heme-dependent dioxygenase that catalyzes the oxidative epoxidation of (S)-2-hydroxypropylphosphonate into (1R,2S)- epoxypropylphosphonate, the final step in the biosynthesis of fosfomycin antibiotic. {ECO:0000269|PubMed:16015285, ECO:0000269|PubMed:16186494}. |
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| Catalytic activity: | |
Reaction=(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)- epoxypropylphosphonate + 2 H2O; Xref=Rhea:RHEA:10808, ChEBI:CHEBI:15377, ChEBI:CHEBI:16240, ChEBI:CHEBI:62246, ChEBI:CHEBI:62247; EC=1.11.1.23; Evidence={ECO:0000269|PubMed:16015285}; |
| Cofactor: | |
Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Evidence={ECO:0000269|PubMed:16015285}; Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000269|PubMed:16015285}; |
| Pathway: | |
Antibiotic biosynthesis; fosfomycin biosynthesis. {ECO:0000269|PubMed:16015285, ECO:0000269|PubMed:19516340}. |
| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:16015285, ECO:0000269|PubMed:16186494, ECO:0000269|PubMed:21682308}. |
| Miscellaneous: | |
Phosphinothricin tripeptide (PTT) herbicide and fosfomycin antibiotic biosynthesis pathways share early steps starting with phosphoenolpyruvate before the pathways diverge after formation of 2-hydroxyethylphosphonate (HEP). HppE is involved in fosfomycin biosynthesis after divergence of the 2 pathways. {ECO:0000305|PubMed:19516340}. |
| Similarity: | |
Belongs to the non-heme iron-dependent dioxygenase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.