UniProt functional annotation for P98002

UniProt code: P98002.

Organism: Paracoccus denitrificans.
Taxonomy: Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales; Rhodobacteraceae; Paracoccus.
Function: Subunit I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). This cytochrome c oxidase shows proton pump activity across the membrane in addition to the electron transfer.
Catalytic activity: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O.
Cofactor: Binds 1 copper B ion per subunit.
Cofactor: Binds 2 heme groups per subunit.
Pathway: Energy metabolism; oxidative phosphorylation.
Subcellular location: Cell inner membrane; Multi-pass membrane protein.
Ptm: His-276 and Tyr-280 are involved in the formation of a copper-coordinated covalent cross-link at the active site of the catalytic subunit I.
Similarity: Belongs to the heme-copper respiratory oxidase family.

Annotations taken from UniProtKB at the EBI.