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UniProt functional annotation for Q06449 | ||
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| UniProt code: Q06449. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Overproduction promotes the de novo induction of the [PSI+] prion form of SUP35. The prion-inducing effect depends on the association with the actin cytoskeleton. Also implicated in prion maintenance during heat stress. {ECO:0000269|PubMed:21777813}. |
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| Subunit: | |
Interacts with LAS17, RSP5 and SUP35. {ECO:0000269|PubMed:10512884, ECO:0000269|PubMed:21777813, ECO:0000269|PubMed:22000681}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus {ECO:0000269|PubMed:14562095}. Cytoplasm, cytoskeleton, actin patch {ECO:0000269|PubMed:21777813}. Note=When overexpressed, localizes to punctate structures which are reminiscent of cortical actin patches (PubMed:21777813). Transiently colocalizes with SUP35 aggregates during prionogenesis (PubMed:21777813). {ECO:0000269|PubMed:21777813}. |
| Induction: | |
By heat shock. Can thereby reach physiological protein levels high enough to promote prion-formation. {ECO:0000269|PubMed:21777813}. |
| Domain: | |
The PY motif is recognized directly by the WW domains of RSP5. |
| Ptm: | |
Ubiquitinated by RSP5. Ubiquitination reduces the protein abundance and its prion-inducing ability. {ECO:0000269|PubMed:21777813, ECO:0000269|PubMed:22000681}. |
| Miscellaneous: | |
Present with 2190 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Miscellaneous: | |
Although this protein promotes prion formation and it has a Asn/Gln-rich prion-like domain, it does not seem to have a prion form by itself. |
| Similarity: | |
Belongs to the LSB1 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.