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UniProt functional annotation for Q9UWW1 | ||
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| UniProt code: Q9UWW1. |
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| Organism: | |
Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus). |
| Taxonomy: | |
Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Saccharolobus. |
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| Function: | |
Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. Possesses a template- independent 3'-terminal nucleotidyl transferase activity. {ECO:0000255|HAMAP-Rule:MF_00701, ECO:0000269|PubMed:15561142}. |
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| Cofactor: | |
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000255|HAMAP-Rule:MF_00701, ECO:0000269|PubMed:17704817}; Note=Binds 1 [4Fe-4S] cluster. {ECO:0000255|HAMAP-Rule:MF_00701, ECO:0000269|PubMed:17704817}; |
| Subunit: | |
Heterodimer of a small subunit (PriS) and a large subunit (PriL). {ECO:0000255|HAMAP-Rule:MF_00701, ECO:0000269|PubMed:15561142, ECO:0000269|PubMed:16273105}. |
| Similarity: | |
Belongs to the eukaryotic-type primase large subunit family. {ECO:0000255|HAMAP-Rule:MF_00701}. |
Annotations taken from UniProtKB at the EBI.