PDBsum entry 1zs5

Transferase

PDB id

1zs5

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Contents

			Protein chain

					118 a.a. *

			Ligands

					MIB

* Residue conservation analysis

PDB id:

1zs5

Links

Name:

Transferase

Title:

Structure-based evaluation of selective and non-selective small molecules that block HIV-1 tat and pcaf association

Structure:

Histone acetyltransferase pcaf. Chain: a. Fragment: bromodomain. Synonym: p300/cbp-associated factor, p/caf, histone acetylase pcaf. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: pcaf. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

NMR struc:

1 models

Authors:

L.Zeng,S.Godbole,M.Muller,S.Yan,R.Sanchez,M.Zhou

Key ref:

L.Zeng et al. Structure-Based evaluation of selective NAD non-Selective small molecules that block HIV-1 tat and pcaf association. To be published, .

Date:

23-May-05

Release date:

23-May-06

PROCHECK

	Headers

	References

Protein chain

Q92831 (KAT2B_HUMAN) - Histone acetyltransferase KAT2B from Homo sapiens

Seq: Struc:

Seq: Struc:					832 a.a. 118 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 3 residue positions (black crosses)



		Enzyme reactions

Enzyme class 1:

E.C.2.3.1.48 - histone acetyltransferase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

L-lysyl-[protein] + acetyl-CoA = N₆-acetyl-L-lysyl-[protein] + CoA + H⁺

L-lysyl-[protein]	+	acetyl-CoA	=	N(6)-acetyl-L-lysyl-[protein]	+	CoA	+	H(+)

Enzyme class 2:

E.C.2.3.1.57 - diamine N-acetyltransferase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

an alkane-alpha,omega-diamine + acetyl-CoA = an N-acetylalkane- alpha,omega-diamine + CoA + H⁺

alkane-alpha,omega-diamine	+	acetyl-CoA	=	N-acetylalkane- alpha,omega-diamine	+	CoA	+	H(+)

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site