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PDBsum entry 1zoy
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Oxidoreductase
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PDB id
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1zoy
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Contents |
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613 a.a.
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239 a.a.
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138 a.a.
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102 a.a.
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References listed in PDB file
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Key reference
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Title
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Crystal structure of mitochondrial respiratory membrane protein complex ii.
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Authors
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F.Sun,
X.Huo,
Y.Zhai,
A.Wang,
J.Xu,
D.Su,
M.Bartlam,
Z.Rao.
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Ref.
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Cell, 2005,
121,
1043-1057.
[DOI no: ]
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PubMed id
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Abstract
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The mitochondrial respiratory Complex II or succinate:ubiquinone oxidoreductase
(SQR) is an integral membrane protein complex in both the tricarboxylic acid
cycle and aerobic respiration. Here we report the first crystal structure of
Complex II from porcine heart at 2.4 A resolution and its complex structure with
inhibitors 3-nitropropionate and 2-thenoyltrifluoroacetone (TTFA) at 3.5 A
resolution. Complex II is comprised of two hydrophilic proteins, flavoprotein
(Fp) and iron-sulfur protein (Ip), and two transmembrane proteins (CybL and
CybS), as well as prosthetic groups required for electron transfer from
succinate to ubiquinone. The structure correlates the protein environments
around prosthetic groups with their unique midpoint redox potentials. Two
ubiquinone binding sites are discussed and elucidated by TTFA binding. The
Complex II structure provides a bona fide model for study of the mitochondrial
respiratory system and human mitochondrial diseases related to mutations in this
complex.
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Figure 1.
Figure 1. The Role of Complex II in the Mitochondrial
Respiratory Chain
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Figure 5.
Figure 5. Ubiquinone Binding Sites
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The above figures are
reprinted
by permission from Cell Press:
Cell
(2005,
121,
1043-1057)
copyright 2005.
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