|
|
||
|
|
|
|
|
UniProt functional annotation for P0DKX7 | ||
|
|
|
|
|
|
||
| UniProt code: P0DKX7. |
|
||
| Organism: | |
Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251). |
| Taxonomy: | |
Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Bordetella. |
|
||
|
||
| Function: | |
This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function. |
|
||
| Catalytic activity: | |
Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1; |
| Activity regulation: | |
Activated by host calmodulin. |
| Subcellular location: | |
Secreted. |
| Domain: | |
The Gly-rich region is probably involved in binding calcium, which is required for target cell-binding or cytolytic activity. {ECO:0000250}. |
| Ptm: | |
Released in a processed form. |
| Ptm: | |
Palmitoylated by CyaC. The toxin only becomes active when modified in position Lys-983. {ECO:0000269|PubMed:10196151, ECO:0000269|PubMed:7939682}. |
| Similarity: | |
In the N-terminal section; belongs to the adenylyl cyclase class-2 family. {ECO:0000305}. |
| Similarity: | |
In the C-terminal section; belongs to the RTX prokaryotic toxin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.