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PDBsum entry 1zml
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References listed in PDB file
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Key reference
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Title
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Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor xia.
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Authors
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T.I.Lazarova,
L.Jin,
M.Rynkiewicz,
J.C.Gorga,
F.Bibbins,
H.V.Meyers,
R.Babine,
J.Strickler.
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Ref.
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Bioorg Med Chem Lett, 2006,
16,
5022-5027.
[DOI no: ]
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PubMed id
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Abstract
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A series of functionalized aryl boronic acids were synthesized and evaluated as
potential inhibitors of factor XIa. Crystal structures of the protein-inhibitor
complexes led to the design and synthesis of second generation compounds showing
single digit micromolar inhibition against FXIa and selectivity against
thrombin, trypsin, and FXa.
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