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PDBsum entry 1zij
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Leucine zipper
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PDB id
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1zij
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Crystal structures of a single coiled-Coil peptide in two oligomeric states reveal the basis for structural polymorphism.
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Authors
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L.Gonzalez,
R.A.Brown,
D.Richardson,
T.Alber.
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Ref.
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Nat Struct Biol, 1996,
3,
1002-1009.
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PubMed id
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Abstract
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Each protein sequence generally adopts a single native fold, but the sequence
features that confer structural uniqueness are not well understood. To define
the basis for structural heterogeneity, we determined the high resolution X-ray
crystal structures of a single GCN4 leucine-zipper mutant (Asn 16 to
aminobutyric acid) in both dimeric and trimeric coiled-coil conformations. The
mutant sequence is accommodated in two distinct structures by forming
similarly-shaped packing surfaces with different sets of atoms. The trimer
structure, in comparison to a previously-characterized trimeric mutant with
substitutions in eight core residues, shows that the twist of individual helices
and the helix-helix crossing angles can vary significantly to produce the most
favoured packing arrangement.
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Secondary reference #1
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Title
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An engineered allosteric switch in leucine-Zipper oligomerization.
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Authors
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L.Gonzalez,
J.J.Plecs,
T.Alber.
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Ref.
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Nat Struct Biol, 1996,
3,
510-515.
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PubMed id
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Secondary reference #2
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Title
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Crystal structure of an isoleucine-Zipper trimer.
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Authors
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P.B.Harbury,
P.S.Kim,
T.Alber.
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Ref.
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Nature, 1994,
371,
80-83.
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PubMed id
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Secondary reference #3
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Title
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A switch between two-, Three-, And four-Stranded coiled coils in gcn4 leucine zipper mutants.
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Authors
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P.B.Harbury,
T.Zhang,
P.S.Kim,
T.Alber.
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Ref.
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Science, 1993,
262,
1401-1407.
[DOI no: ]
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PubMed id
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Secondary reference #4
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Title
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X-Ray structure of the gcn4 leucine zipper, A two-Stranded, Parallel coiled coil.
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Authors
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E.K.O'Shea,
J.D.Klemm,
P.S.Kim,
T.Alber.
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Ref.
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Science, 1991,
254,
539-544.
[DOI no: ]
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PubMed id
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