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UniProt functional annotation for Q15819 | ||
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| UniProt code: Q15819. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. {ECO:0000269|PubMed:10089880, ECO:0000269|PubMed:14562038, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:9705497}. |
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| Subunit: | |
Heterodimer with UBE2N. Binds CHFR. {ECO:0000269|PubMed:22325355, ECO:0000269|PubMed:22589545}. |
| Tissue specificity: | |
Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues. {ECO:0000269|PubMed:9199207, ECO:0000269|PubMed:9705497}. |
| Induction: | |
Up-regulated in cultured fresh blood cells upon treatment with vitamin D3. {ECO:0000269|PubMed:9199207}. |
| Similarity: | |
Belongs to the ubiquitin-conjugating enzyme family. {ECO:0000255|PROSITE-ProRule:PRU00388}. |
Annotations taken from UniProtKB at the EBI.