UniProt functional annotation for P08153



	UniProt functional annotation for P08153

UniProt code: P08153.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Determines the mother-cell-specific transcription of the HO endonuclease gene that is responsible for the initiation of mating-type switching in yeast. Recognizes a specific sequence in the promoter of the HO gene. Activates EGT2 transcription in a concentration-dependent manner. Synthesized during G2 and early mitosis.

Subcellular location: Nucleus {ECO:0000269|PubMed:1652372}. Cytoplasm {ECO:0000269|PubMed:1652372}. Note=Nuclear in G1, cytoplasmic in S, G2 and M cell cycle phases.

Ptm: Cell cycle-dependent phosphorylation of three serine residues prevents SWI5 from entering the nucleus, and it accumulates in the cytoplasm. As a consequence of CDC28 kinase inactivation at the end of anaphase, the three serine residues are dephosphorylated and SWI5 enters the nucleus to activate transcription. It is then rapidly degraded. Threonine phosphorylation also seems to occur.

Ptm: Phosphorylated by PHO85.

Miscellaneous: Present with 688 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Determines the mother-cell-specific transcription of the HO endonuclease gene that is responsible for the initiation of mating-type switching in yeast. Recognizes a specific sequence in the promoter of the HO gene. Activates EGT2 transcription in a concentration-dependent manner. Synthesized during G2 and early mitosis.


Subcellular location:		Nucleus {ECO:0000269\|PubMed:1652372}. Cytoplasm {ECO:0000269\|PubMed:1652372}. Note=Nuclear in G1, cytoplasmic in S, G2 and M cell cycle phases.
Ptm:		Cell cycle-dependent phosphorylation of three serine residues prevents SWI5 from entering the nucleus, and it accumulates in the cytoplasm. As a consequence of CDC28 kinase inactivation at the end of anaphase, the three serine residues are dephosphorylated and SWI5 enters the nucleus to activate transcription. It is then rapidly degraded. Threonine phosphorylation also seems to occur.
Ptm:		Phosphorylated by PHO85.
Miscellaneous:		Present with 688 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.