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UniProt functional annotation for O54924 | ||
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| UniProt code: O54924. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. |
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| Subunit: | |
The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8 (PubMed:9405631, PubMed:12954101). Interacts (via PH domain) with GTP-bound RALA and RALB (By similarity) (PubMed:15920473). Interacts with SH3BP1; required for the localization of both SH3BP1 and the exocyst to the leading edge of migrating cells (By similarity). {ECO:0000250|UniProtKB:Q8IYI6, ECO:0000269|PubMed:12954101, ECO:0000269|PubMed:15920473, ECO:0000269|PubMed:9405631}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:12954101}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12954101}. Cell projection, growth cone {ECO:0000269|PubMed:12954101}. Cell projection {ECO:0000269|PubMed:21658605}. Note=Binds lipids with phosphatidylinositol 3,4,5-trisphosphate groups (By similarity). Perinuclear in undifferentiated PC12 cells. Redistributes to growing neurites and growth cones during NGF-induced neuronal differentiation (PubMed:12954101). Localizes at the leading edge of migrating cells (PubMed:21658605). {ECO:0000250, ECO:0000269|PubMed:12954101, ECO:0000269|PubMed:21658605}. |
| Similarity: | |
Belongs to the EXO84 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.