UniProt functional annotation for P07451

UniProt code: P07451.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Reversible hydration of carbon dioxide.
 
Catalytic activity: H(2)CO(3) = CO(2) + H(2)O.
Cofactor: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Enzyme regulation: Activated by proton donors such as imidazole and the dipeptide histidylhistidine. Inhibited by coumarins and sulfonamide derivatives such as acetazolamide. {ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230}.
Biophysicochemical properties: Kinetic parameters: KM=52.0 mM for CO(2) {ECO:0000269|PubMed:18618712};
Subcellular location: Cytoplasm.
Tissue specificity: Muscle specific.
Developmental stage: At 6 weeks gestation, transcripts accumulate at low levels in the somites and at high levels throughout the notochord. As gestation continues, CA3 becomes abundant in all developing muscle masses and continues at high to moderate levels in the notochord. {ECO:0000269|PubMed:9651514}.
Ptm: S-glutathionylated in hepatocytes under oxidative stress. {ECO:0000250}.
Similarity: Belongs to the alpha-carbonic anhydrase family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.