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UniProt functional annotation for P05362 | ||
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| UniProt code: P05362. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:17875742}. |
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| Function: | |
(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. {ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243}. |
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| Function: | |
(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:9539703}. |
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| Function: | |
(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T- lymphocytes and NK cell. {ECO:0000269|PubMed:11413168}. |
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| Subunit: | |
Homodimer (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells. {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:12526797, ECO:0000269|PubMed:15099525, ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:23858057, ECO:0000305}. |
| Subunit: | |
(Microbial infection) Interacts with major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243). {ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243}. |
| Subunit: | |
(Microbial infection) Interacts with Coxsackievirus A21 capsid proteins (PubMed:11160747, PubMed:16004874, PubMed:9539703). {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:9539703}. |
| Subcellular location: | |
Membrane; Single-pass type I membrane protein. |
| Ptm: | |
Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. |
| Polymorphism: | |
Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria [MIM:611162]. {ECO:0000269|PubMed:9259284}. |
| Similarity: | |
Belongs to the immunoglobulin superfamily. ICAM family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.