UniProt functional annotation for P08546

UniProt code: P08546.

Organism:		Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
Taxonomy:		Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
Function:		Replicates viral genomic DNA in the late phase of lytic infection, producing long concatemeric DNA. The replication complex is composed of six viral proteins: the DNA polymerase, processivity factor, primase, primase-associated factor, helicase, and ssDNA-binding protein (By similarity). {ECO:0000250}.
Catalytic activity:		Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
Subunit:		Forms a complex with the ssDNA-binding protein UL57, the DNA polymerase processivity factor UL44, and the alkaline exonuclease UL98. Interacts with the putative helicase-primase complex composed of UL70, UL102 and UL105 proteins; these interactions may coordinate leading and lagging strand DNA synthesis at the replication fork (By similarity). {ECO:0000250}.
Subcellular location:		Host nucleus {ECO:0000250}. Note=the protein is present at discrete sites in nuclei, called replication compartments where viral DNA replication occurs. {ECO:0000250}.
Similarity:		Belongs to the DNA polymerase type-B family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.