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UniProt functional annotation for P04332 | ||
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| UniProt code: P04332. |
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| Organism: | |
Bacillus phage phi29 (Bacteriophage phi-29). |
| Taxonomy: | |
Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes; Caudovirales; Podoviridae; Picovirinae; Salasvirus. |
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| Function: | |
Forms the portal vertex of the capsid (PubMed:10801350) (PubMed:19744688, PubMed:21570409). This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection (By similarity). The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel (PubMed:11812138, PubMed:21570409). Binds to the 6 packaging RNA molecules (pRNA) forming a double-ring structure which in turn binds to the ATPase gp16 hexamer, forming the active DNA-translocating motor (PubMed:15886394, PubMed:11130079). This complex is essential for the specificity of packaging from the left DNA end. {ECO:0000250|UniProtKB:P13334, ECO:0000269|PubMed:11130079, ECO:0000269|PubMed:11812138, ECO:0000269|PubMed:15886394, ECO:0000269|PubMed:19744688, ECO:0000269|PubMed:21570409, ECO:0000305|PubMed:10801350}. |
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| Subunit: | |
Homododecamer (PubMed:11130079, PubMed:11526317) (PubMed:11812138). Interacts (via N-terminus) with the pRNA (PubMed:15886394). {ECO:0000269|PubMed:11130079, ECO:0000269|PubMed:11526317, ECO:0000269|PubMed:11812138, ECO:0000269|PubMed:15886394}. |
| Subcellular location: | |
Virion {ECO:0000269|PubMed:11562162}. Note=Present in 12 copies in the virion. {ECO:0000269|PubMed:11562162, ECO:0000269|PubMed:11812138}. |
| Similarity: | |
Belongs to the phi29likevirus portal protein family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.