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UniProt functional annotation for P01135 | ||
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| UniProt code: P01135. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. |
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| Subunit: | |
Interacts with the PDZ domains of MAGI3, SDCBP and SNTA1. The interaction with SDCBP, is required for the targeting to the cell surface. In the endoplasmic reticulum, in its immature form (i.e. with a prosegment and lacking full N-glycosylation), interacts with CNIH. In the Golgi apparatus, may form a complex with CNIH and GORASP2. Interacts (via cytoplasmic C-terminal domain) with NKD2. {ECO:0000269|PubMed:10230395, ECO:0000269|PubMed:17607000, ECO:0000269|PubMed:18757723}. |
| Subcellular location: | |
[Transforming growth factor alpha]: Secreted, extracellular space. |
| Subcellular location: | |
[Protransforming growth factor alpha]: Cell membrane; Single-pass type I membrane protein. |
| Tissue specificity: | |
Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. {ECO:0000269|PubMed:10523832}. |
Annotations taken from UniProtKB at the EBI.