PDBsum entry 1yr5

Metal binding protein/transferase

PDB id: 1yr5

Contents

Protein chains

146 a.a. *

19 a.a. *

Metals

_CA ×4

Waters ×144

* Residue conservation analysis

PDB id:

1yr5

Name:

Metal binding protein/transferase

Title:

1.7-a structure of calmodulin bound to a peptide from dap kinase

Structure:

Calmodulin. Chain: a. Fragment: residues 1-148. Engineered: yes. 19-mer from death-associated protein kinase 1. Chain: b. Synonym: dap kinase 1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide

Biol. unit:

Tetramer (from PQS)

Resolution:

1.70Å R-factor: 0.203 R-free: 0.257

Authors:

P.Kursula,J.Vahokoski,M.Wilmanns

Key ref:

P.Kursula et al. Recognition of human death-Associated protein kinases by calmodulin. To be published, .

Date:

03-Feb-05 Release date: 04-Jul-06

Protein chain

P0DP23  (CALM1_HUMAN) -  Calmodulin-1 from Homo sapiens

Seq: 149 a.a.

Struc: 146 a.a.

Protein chain

P53355  (DAPK1_HUMAN) -  Death-associated protein kinase 1 from Homo sapiens

Seq: 1430 a.a.

Struc: 19 a.a.

Enzyme reactions

• Enzyme class: Chain B: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site