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UniProt functional annotation for Q12163 | ||
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| UniProt code: Q12163. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Negatively regulates the high-osmolarity glycerol (HOG) pathway through its negative regulation of the HOG1 kinase activity. Mediates the binding between the PTC1 phosphatase and the PBS2 MAP/ERK kinase (MEK). With PTC1, regulates endoplasmic reticulum inheritance through the cell wall integrity (CWI) MAPK pathway by modulating the MAPK, SLT2. {ECO:0000269|PubMed:14573466, ECO:0000269|PubMed:14685261, ECO:0000269|PubMed:16977319}. |
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| Subunit: | |
Interacts with PBS2 and PTC1. {ECO:0000269|PubMed:14685261}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:14573466}. |
| Miscellaneous: | |
Present with 521 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
Annotations taken from UniProtKB at the EBI.