UniProt functional annotation for P30305

UniProt code: P30305.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity. {ECO:0000269|PubMed:17332740}.
 
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
Enzyme regulation: Stimulated by B-type cyclins.
Subunit: Interacts with MAPK14 and 14-3-3 proteins. {ECO:0000269|PubMed:11333986}.
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
Ptm: Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-353 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-169 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-323 and Ser-375 by MAPK14 is required for binding to 14-3-3 proteins. {ECO:0000269|PubMed:11333986, ECO:0000269|PubMed:12400006, ECO:0000269|PubMed:15128871, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:15311285, ECO:0000269|PubMed:15629715, ECO:0000269|PubMed:15908796, ECO:0000269|PubMed:17332740}.
Similarity: Belongs to the MPI phosphatase family. {ECO:0000305}.
Similarity: Contains 1 rhodanese domain. {ECO:0000255|PROSITE- ProRule:PRU00173}.

Annotations taken from UniProtKB at the EBI.