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PDBsum entry 1y91
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References listed in PDB file
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Key reference
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Title
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Structure-Guided design of pyrazolo[1,5-A]pyrimidines as inhibitors of human cyclin-Dependent kinase 2.
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Authors
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D.S.Williamson,
M.J.Parratt,
J.F.Bower,
J.D.Moore,
C.M.Richardson,
P.Dokurno,
A.D.Cansfield,
G.L.Francis,
R.J.Hebdon,
R.Howes,
P.S.Jackson,
A.M.Lockie,
J.B.Murray,
C.L.Nunns,
J.Powles,
A.Robertson,
A.E.Surgenor,
C.J.Torrance.
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Ref.
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Bioorg Med Chem Lett, 2005,
15,
863-867.
[DOI no: ]
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PubMed id
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Abstract
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The protein structure guided design of a series of pyrazolo[1,5-a]pyrimidines
with high potency for human cyclin-dependent kinase 2 (CDK2) is described. Some
examples were shown to inhibit the growth of human colon tumour cells, were
equipotent for CDK1 and were selective against GSK-3beta and other kinases.
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