UniProt functional annotation for P08263

UniProt code: P08263.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
 
Catalytic activity: RX + glutathione = HX + R-S-glutathione.
Subunit: Homodimer or heterodimer of GSTA1 and GSTA2.
Subcellular location: Cytoplasm.
Tissue specificity: Liver.
Domain: The C-terminal domain may form a component of the hydrophobic substrate-binding site, but in contrast appears not to be directly involved in GSH binding and is not absolutely essential for catalytic activity.
Similarity: Belongs to the GST superfamily. Alpha family.
Similarity: Contains 1 GST C-terminal domain.
Similarity: Contains 1 GST N-terminal domain.

Annotations taken from UniProtKB at the EBI.