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UniProt functional annotation for Q96LD8 | ||
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| UniProt code: Q96LD8. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. {ECO:0000269|PubMed:12730221, ECO:0000269|PubMed:12759362, ECO:0000269|PubMed:12759363, ECO:0000269|PubMed:15242646, ECO:0000269|PubMed:15775960}. |
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| Biophysicochemical properties: | |
Kinetic parameters: KM=51 nM for Nedd8-AMC {ECO:0000269|PubMed:12759362}; Note=KM for Ub-AMC exceeds 5 uM.; |
| Tissue specificity: | |
Broadly expressed, with highest levels in kidney and pancreas. {ECO:0000269|PubMed:12730221}. |
| Similarity: | |
Belongs to the peptidase C48 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.