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PDBsum entry 1xog

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Hydrolase PDB id
1xog
Jmol
Contents
Protein chain
387 a.a.
Ligands
NAG-NAG-BMA-MAN-
MAN-MAN
MAN
NAG ×2
ABW

References listed in PDB file
Key reference
Title Design, Synthesis, And structural analysis of inhibitors of influenza neuraminidase containing a 2,3-Disubstituted tetrahydrofuran-5-Carboxylic acid core.
Authors G.T.Wang, S.Wang, R.Gentles, T.Sowin, C.J.Maring, D.J.Kempf, W.M.Kati, V.Stoll, K.D.Stewart, G.Laver.
Ref. Bioorg Med Chem Lett, 2005, 15, 125-128. [DOI no: 10.1016/j.bmcl.2004.10.022]
PubMed id 15582424
Abstract
(+/-)-(2R,3R,5R)-[2-(1'-S-acetamido-3'-methyl)butyl-3-methoxycarbonyl]tetrahydrofuran-5-carboxylic acid (9) and (+/-)-(2R,3R,5R)-[2-(1'-S-acetamido-3'-methyl)butyl-3-(4'-imidazolyl)]tetrahydrofuran 5-carboxylic acid (14) were synthesized as inhibitors of influenza neuraminidase (NA). Both compounds 9 and 14 inhibit influenza NA A with an IC(50) of about 0.5 microM and NA B with an IC(50) of 1.0 microM.
PROCHECK
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 Headers