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UniProt functional annotation for O35627 | ||
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| UniProt code: O35627. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity). {ECO:0000250, ECO:0000269|PubMed:10462436}. |
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| Subunit: | |
Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Interacts with ECT2. Directly interacts with DNAJC7; this complex may also include HSP90. Interacts with CRY1 (PubMed:28751364). Interacts with CRY2 in a ligand-dependent manner (PubMed:28751364). {ECO:0000269|PubMed:14573755, ECO:0000269|PubMed:15610733, ECO:0000269|PubMed:17904126, ECO:0000269|PubMed:28751364, ECO:0000269|PubMed:8603043}. |
| Subcellular location: | |
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Recruited to the cytoplasm by DNAJC7. |
| Tissue specificity: | |
Predominantly expressed in liver. |
| Domain: | |
Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains. |
| Ptm: | |
Phosphorylated at Thr-48 by PKC, dephosphorylation of Thr-48 is required for nuclear translocation and activation. {ECO:0000250}. |
| Miscellaneous: | |
[Isoform CAR2]: Does not seem to act as a transactivator. Lacks the C-terminal portion of the ligand binding/dimerization domain. {ECO:0000305}. |
| Similarity: | |
Belongs to the nuclear hormone receptor family. NR1 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.