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UniProt functional annotation for P08716 | ||
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| UniProt code: P08716. |
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| Organism: | |
Escherichia coli. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Part of the ABC transporter complex HlyBD involved in hemolysin export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. |
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| Subunit: | |
Homodimer. |
| Subcellular location: | |
Cell inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Domain: | |
In HlyB the peptidase C39 domain, the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused. |
| Miscellaneous: | |
The complex HlyBD-TolC (OMF) forms a single transport channel across the two membranes, allowing direct export of alpha- hemolysin. This channel is involved in type 1 secretion system. |
| Similarity: | |
Belongs to the ABC transporter superfamily. Protein-1 exporter (TC 3.A.1.109) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.