UniProt functional annotation for P04746

UniProt code: P04746.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Catalytic activity: Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha- linked D-glucose units. {ECO:0000269|PubMed:10091666, ECO:0000269|PubMed:10769135, ECO:0000269|PubMed:11772019, ECO:0000269|PubMed:11914097}.
Cofactor: Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000269|PubMed:10091666, ECO:0000269|PubMed:10769135, ECO:0000269|PubMed:11772019, ECO:0000269|PubMed:11914097, ECO:0000269|PubMed:8528071}; Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000269|PubMed:10091666, ECO:0000269|PubMed:10769135, ECO:0000269|PubMed:11772019, ECO:0000269|PubMed:11914097, ECO:0000269|PubMed:8528071};
Cofactor: Name=chloride; Xref=ChEBI:CHEBI:17996; Evidence={ECO:0000269|PubMed:10091666, ECO:0000269|PubMed:10769135, ECO:0000269|PubMed:11772019, ECO:0000269|PubMed:11914097, ECO:0000269|PubMed:8528071}; Note=Binds 1 Cl(-) ion per subunit. {ECO:0000269|PubMed:10091666, ECO:0000269|PubMed:10769135, ECO:0000269|PubMed:11772019, ECO:0000269|PubMed:11914097, ECO:0000269|PubMed:8528071};
Subunit: Monomer.
Subcellular location: Secreted, extracellular space.
Tissue specificity: Detected in pancreas (at protein level). {ECO:0000269|PubMed:8528071}.
Similarity: Belongs to the glycosyl hydrolase 13 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.