PDBsum entry 1x6g

Signaling protein

PDB id: 1x6g

Contents

Protein chain

81 a.a. *

* Residue conservation analysis

PDB id:

1x6g

Name:

Signaling protein

Title:

Solution structures of the sh3 domain of human megakaryocyte- associated tyrosine-protein kinase.

Structure:

Megakaryocyte-associated tyrosine-protein kinase. Chain: a. Fragment: sh3 domain. Synonym: tyrosine-protein kinase ctk, protein kinase hyl, hematopoietic consensus tyrosine-lacking kinase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: matk. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

M.Sato,S.Koshiba,M.Inoue,T.Kigawa,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

M.Sato et al. Solution structures of the sh3 domain of human megakaryocyte-Associated tyrosine-Protein kinase.. To be published, .

Date:

17-May-05 Release date: 17-Nov-05

Protein chain

P42679  (MATK_HUMAN) -  Megakaryocyte-associated tyrosine-protein kinase from Homo sapiens

Seq: 507 a.a.

Struc: 81 a.a.*

* PDB and UniProt seqs differ at 11 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site