UniProt functional annotation for O75886



	UniProt functional annotation for O75886

UniProt code: O75886.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}.

Subunit: Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 and EPS15. Interacts with JAK2 and JAK3. Interacts with ubiquitinated proteins and the deubiquitinating enzyme USP8/UBPY (By similarity). Interacts (via the via the PxVxL motif) with CBX5; the interaction is direct. Interacts with VPS37C. Interacts with ubiquitin; the interaction is direct. Interacts (via UIM domain) with UBQLN1 (via ubiquitin-like domain) (By similarity). {ECO:0000250|UniProtKB:O88811, ECO:0000269|PubMed:10899310, ECO:0000269|PubMed:12551915, ECO:0000269|PubMed:15509564, ECO:0000269|PubMed:15882967}.

Subcellular location: Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000269|PubMed:12551915}; Peripheral membrane protein {ECO:0000269|PubMed:12551915}; Cytoplasmic side {ECO:0000269|PubMed:12551915}.

Tissue specificity: Ubiquitously expressed. {ECO:0000269|PubMed:10899310}.

Domain: The VHS and UIM domains mediate the interaction with ubiquitinated proteins.

Domain: The SH3 domain mediates the interaction with USP8.

Domain: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.

Ptm: Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.

Similarity: Belongs to the STAM family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}.


Subunit:		Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS. Part of a complex at least composed of HSG, STAM2 and EPS15. Interacts with JAK2 and JAK3. Interacts with ubiquitinated proteins and the deubiquitinating enzyme USP8/UBPY (By similarity). Interacts (via the via the PxVxL motif) with CBX5; the interaction is direct. Interacts with VPS37C. Interacts with ubiquitin; the interaction is direct. Interacts (via UIM domain) with UBQLN1 (via ubiquitin-like domain) (By similarity). {ECO:0000250\|UniProtKB:O88811, ECO:0000269\|PubMed:10899310, ECO:0000269\|PubMed:12551915, ECO:0000269\|PubMed:15509564, ECO:0000269\|PubMed:15882967}.
Subcellular location:		Cytoplasm {ECO:0000250}. Early endosome membrane {ECO:0000269\|PubMed:12551915}; Peripheral membrane protein {ECO:0000269\|PubMed:12551915}; Cytoplasmic side {ECO:0000269\|PubMed:12551915}.
Tissue specificity:		Ubiquitously expressed. {ECO:0000269\|PubMed:10899310}.
Domain:		The VHS and UIM domains mediate the interaction with ubiquitinated proteins.
Domain:		The SH3 domain mediates the interaction with USP8.
Domain:		Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
Ptm:		Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.
Similarity:		Belongs to the STAM family. {ECO:0000305}.