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UniProt functional annotation for Q9H0F5 | ||
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| UniProt code: Q9H0F5. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme. {ECO:0000269|PubMed:23973461}. |
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| Catalytic activity: | |
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; |
| Pathway: | |
Protein modification; protein ubiquitination. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:23973461}. |
| Tissue specificity: | |
Widely expressed with highest levels in testis. {ECO:0000269|PubMed:12074600}. |
Annotations taken from UniProtKB at the EBI.