PDBsum entry 1wyl

Signaling protein

PDB id: 1wyl

Contents

Protein chain

116 a.a. *

* Residue conservation analysis

PDB id:

1wyl

Name:

Signaling protein

Title:

Solution structure of the ch domain of human nedd9 interacting protein with calponin homology and lim domains

Structure:

Nedd9 interacting protein with calponin homology and lim domains. Chain: a. Fragment: ch domain. Synonym: molecule interacting with casl protein 1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: nical. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

T.Tomizawa,T.Kigawa,S.Koshiba,M.Inoue,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

T.Tomizawa et al. Solution structure of the ch domain of human nedd9 interacting protein with calponin homology and lim domains. To be published, .

Date:

15-Feb-05 Release date: 15-Aug-05

Protein chain

Q8TDZ2  (MICA1_HUMAN) -  [F-actin]-monooxygenase MICAL1 from Homo sapiens

Seq: 1067 a.a.

Struc: 116 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class 2: E.C.1.14.13.225 - F-actin monooxygenase.
• Reaction: L-methionyl-[F-actin] + NADPH + O2 + H⁺ = L-methionyl-(R)-S-oxide- [F-actin] + NADP⁺ + H2O
• Enzyme class 3: E.C.1.6.3.1 - NAD(P)H oxidase (H2O2-forming).
• Reaction:
  1. NADPH + O2 + H⁺ = H2O2 + NADP⁺
  2. NADH + O2 + H⁺ = H2O2 + NAD⁺
• Cofactor: Ca(2+); FAD; Heme

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site