PDBsum entry 1wy8

Ligase

PDB id: 1wy8

Contents

Protein chain

89 a.a. *

* Residue conservation analysis

PDB id:

1wy8

Name:

Ligase

Title:

Solution structure of the n-terminal ubiquitin-like domain in human np95/icbp90-like ring finger protein (nirf)

Structure:

Np95-like ring finger protein, isoform a. Chain: a. Fragment: ubiquitin-like domain. Synonym: np95/icbp90-like ring finger protein, nirf. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: uhrf2. Other_details: cell-free synthesis

NMR struc:

20 models

Authors:

C.Zhao,K.Saito,S.Koshiba,M.Inoue,T.Kigawa,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

C.Zhao et al. Solution structure of the n-Terminal ubiquitin-Like domain in human np95/icbp90-Like ring finger protein (nirf). To be published, .

Date:

09-Feb-05 Release date: 09-Aug-05

Protein chain

Q96PU4  (UHRF2_HUMAN) -  E3 ubiquitin-protein ligase UHRF2 from Homo sapiens

Seq: 802 a.a.

Struc: 89 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.3.2.27 - RING-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine