PDBsum entry 1wvx

Transferase

PDB id: 1wvx

Contents

Protein chain

275 a.a. *

Ligands

BD4

Waters ×74

* Residue conservation analysis

PDB id:

1wvx

Name:

Transferase

Title:

Crystal structures of kinase domain of dap kinase in complex with small molecular inhibitors

Structure:

Death-associated protein kinase 1. Chain: a. Fragment: catalytic domain. Synonym: dap kinase 1. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

2.60Å R-factor: 0.225 R-free: 0.270

Authors:

Y.Ueda,H.Ogata,A.Yamakawa,Y.Higuchi

Key ref:

Y.Ueda et al. Complex structure of kinase domain of dap kinase with bdb402. To be published, .

Date:

27-Dec-04 Release date: 11-Apr-06

Protein chain

P53355  (DAPK1_HUMAN) -  Death-associated protein kinase 1 from Homo sapiens

Seq: 1430 a.a.

Struc: 275 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site