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UniProt functional annotation for Q9IAM1 | ||
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| UniProt code: Q9IAM1. |
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| Organism: | |
Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Deinagkistrodon. |
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| Function: | |
Anticoagulant protein which binds to the gamma- carboxyglutamic acid-domain regions of factors IX (F9) and factor X (F10) in the presence of calcium with a 1 to 1 stoichiometry. Also inhibits platelet aggregation by binding to platelet glycoprotein Ibalpha (GP1BA) and functioning as a blocker of von Willebrand factor (VWF). Is devoid of hemorrhagic and lethal activities. Possesses antithrombotic and thrombolytic activities. Also hydrolyzes the Aalpha- chain of fibrinogen (FGA). Does not affect the Bbeta-chain (FGB) and the gamma chain (FGG). {ECO:0000269|PubMed:10558903, ECO:0000269|PubMed:12058182, ECO:0000269|PubMed:15925567}. |
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| Subunit: | |
Heterodimer with subunit B of AaACP or agkisacutacin; disulfide-linked. {ECO:0000269|PubMed:11404471, ECO:0000269|Ref.5}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Similarity: | |
Belongs to the snaclec family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.