 |
PDBsum entry 1wmk
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Transferase
|
|
|
Title:
|
|
Human death-associated kinase drp-1, mutant s308d d40
|
|
Structure:
|
|
Death-associated protein kinase 2. Chain: a, e, c, b, f, d, h, g. Fragment: residues 1-320. Synonym: dap kinase 2, dap- kinase related protein 1, drp-1. Engineered: yes. Mutation: yes
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
Resolution:
|
|
|
3.60Å
|
R-factor:
|
0.277
|
R-free:
|
0.296
|
|
|
Authors:
|
|
P.Kursula,G.Shani,A.Kimchi,M.Wilmanns
|
|
Key ref:
|
|
P.Kursula
et al.
Structure of the inhibited conformation of drp-1 kinase.
To be published,
.
|
|
|
Date:
|
|
|
11-Jul-04
|
Release date:
|
31-Jan-06
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
Q9UIK4
(DAPK2_HUMAN) -
Death-associated protein kinase 2 from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
370 a.a.
303 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.2.7.11.1
- non-specific serine/threonine protein kinase.
|
|
|
|
|
|
|
Reaction:
|
|
|
1.
|
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
|
|
2.
|
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
|
|
|
|
|
|
|
L-seryl-[protein]
|
+
|
ATP
|
=
|
O-phospho-L-seryl-[protein]
|
+
|
ADP
|
+
|
H(+)
|
|
|
|
|
|
|
L-threonyl-[protein]
|
+
|
ATP
|
=
|
O-phospho-L-threonyl-[protein]
|
+
|
ADP
|
+
|
H(+)
|
|
|
|
|
|
|
|
|
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
Links
