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UniProt functional annotation for P00743 | ||
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| UniProt code: P00743. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. |
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| Catalytic activity: | |
Reaction=Selective cleavage of Arg-|-Thr and then Arg-|-Ile bonds in prothrombin to form thrombin.; EC=3.4.21.6; |
| Activity regulation: | |
Inhibited by SERPINA5. {ECO:0000250}. |
| Subunit: | |
The two chains are formed from a single-chain precursor by the excision of two Arg residues and are held together by 1 or more disulfide bonds. Forms a heterodimer with SERPINA5 (By similarity). {ECO:0000250}. |
| Subcellular location: | |
Secreted. |
| Ptm: | |
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium. |
| Ptm: | |
N- and O-glycosylated. {ECO:0000269|PubMed:1059093, ECO:0000269|PubMed:8243461}. |
| Ptm: | |
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway). {ECO:0000269|PubMed:1059122}. |
| Ptm: | |
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. {ECO:0000269|PubMed:6688526}. |
| Miscellaneous: | |
Calcium also binds, with stronger affinity to another site, beyond the GLA domain. |
| Similarity: | |
Belongs to the peptidase S1 family. {ECO:0000255|PROSITE- ProRule:PRU00274}. |
Annotations taken from UniProtKB at the EBI.