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UniProt functional annotation for Q9BZ29 | ||
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| UniProt code: Q9BZ29. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154}. |
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| Subunit: | |
Homodimer (Probable). Interacts preferentially with nucleotide-depleted CDC42. {ECO:0000269|PubMed:12172552, ECO:0000269|PubMed:19745154, ECO:0000305}. |
| Subcellular location: | |
Endomembrane system {ECO:0000305}. Note=Associated with membranes. {ECO:0000305}. |
| Tissue specificity: | |
Widely expressed, with highest expression in heart and placenta. Expressed at intermediate level in kidney, brain, lung and skeletal muscle. {ECO:0000269|PubMed:12172552}. |
| Domain: | |
The DOCKER domain is necessary and sufficient for the GEF activity. |
| Miscellaneous: | |
'Zizim' means 'spike' in Hebrew. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform 4]: Produced by exon skipping that results in a frameshift. {ECO:0000305}. |
| Similarity: | |
Belongs to the DOCK family. {ECO:0000255|PROSITE- ProRule:PRU00983}. |
| Sequence caution: | |
Sequence=BAA83010.2; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.