PDBsum entry 1wep

DNA binding protein

PDB id

1wep

Loading ...

Contents

			Protein chain

					79 a.a. *

			Metals

					_ZN ×2

* Residue conservation analysis

PDB id:

1wep

Links
- PDBe
- RCSB
- MMDB
- JenaLib
- Proteopedia
- CATH
- SCOP
- PDBSWS
- ProSAT

Name:

DNA binding protein

Title:

Solution structure of phd domain in phf8

Structure:

Phf8. Chain: a. Fragment: phd domain. Engineered: yes

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Gene: riken cdna 4921501e09. Other_details: cell free protein synthesis

NMR struc:

20 models

Authors:

F.He,M.Inoue,T.Kigawa,M.Shirouzu,T.Terada,Y.Muto,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

F.He et al. Solution structure of phd domain in protein aa017385. To be published, .

Date:

25-May-04

Release date:

25-Nov-04

PROCHECK

	Headers

	References

Protein chain

Q80TJ7 (PHF8_MOUSE) - Histone lysine demethylase PHF8 from Mus musculus

Seq: Struc:

Seq: Struc:

Seq: Struc:					1023 a.a. 79 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 21 residue positions (black crosses)



		Enzyme reactions

Enzyme class 2:

E.C.1.14.11.27 - [histone H3]-dimethyl-L-lysine(36) demethylase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

N₆,N₆-dimethyl-L-lysyl₃₆-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl₃₆-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2

N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3]	+	2 × 2-oxoglutarate	+	2 × O2	=	L-lysyl(36)-[histone H3]	+	2 × formaldehyde	+	2 × succinate	+	2 × CO2

Cofactor:

Fe(2+)

Enzyme class 3:

E.C.1.14.11.65 - [histone H3]-dimethyl-L-lysine(9) demethylase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

N₆,N₆-dimethyl-L-lysyl₉-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl₉-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2

N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3]	+	2 × 2-oxoglutarate	+	2 × O2	=	L-lysyl(9)-[histone H3]	+	2 × formaldehyde	+	2 × succinate	+	2 × CO2

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site