PDBsum entry 1w8b

Hydrolase

PDB id: 1w8b

Contents

Protein chains

247 a.a.

56 a.a.

Ligands

413

Metals

_CA

Waters ×59

References listed in PDB file

Key reference

• Title: Selective and orally bioavailable phenylglycine tissue factor/factor viia inhibitors.
• Authors: K.G.Zbinden, U.Obst-Sander, K.Hilpert, H.Kühne, D.W.Banner, H.J.Böhm, M.Stahl, J.Ackermann, L.Alig, L.Weber, H.P.Wessel, M.A.Riederer, T.B.Tschopp, T.Lavé.
• Ref.: Bioorg Med Chem Lett, 2005, 15, 5344-5352. [DOI no: 10.1016/j.bmcl.2005.04.079]
• PubMed id: 16213138

Abstract

We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere with the coagulation cascade by selective inhibition of the extrinsic pathway.