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UniProt functional annotation for P16250 | ||
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| UniProt code: P16250. |
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| Organism: | |
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145). |
| Taxonomy: | |
Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group. |
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| Function: | |
Catalyzes the isomerization of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR in the biosynthesis pathway for histidine and the isomerization of the aminoaldose PRA to the aminoketose CdRP in the biosynthsis pathway for tryptophan. |
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| Catalytic activity: | |
Reaction=1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D- ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5- phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide; Xref=Rhea:RHEA:15469, ChEBI:CHEBI:58435, ChEBI:CHEBI:58525; EC=5.3.1.16; Evidence={ECO:0000269|PubMed:15654319}; |
| Catalytic activity: | |
Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2- carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate; Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613; EC=5.3.1.24; Evidence={ECO:0000269|PubMed:15654319}; |
| Biophysicochemical properties: | |
Kinetic parameters: KM=28 uM for ProFAR {ECO:0000269|PubMed:15654319}; KM=4 uM for PRA {ECO:0000269|PubMed:15654319}; |
| Pathway: | |
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. |
| Pathway: | |
Amino-acid biosynthesis; L-tryptophan biosynthesis; L- tryptophan from chorismate: step 3/5. |
| Subunit: | |
Monomer. {ECO:0000269|PubMed:15654319}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. |
| Similarity: | |
Belongs to the HisA/HisF family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.