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UniProt functional annotation for P68638 | ||
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| UniProt codes: P68638, P10998. |
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| Organism: | |
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)). |
| Taxonomy: | |
Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes; Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus. |
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| Function: | |
Serves to protect the virus against complement attack by inhibiting both classical and alternative pathways of complement activation. Binds C3b and C4b. {ECO:0000269|PubMed:1731333, ECO:0000269|PubMed:18287241}. |
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| Subunit: | |
Heterodimer with A56 protein; disulfide-linked. |
| Subcellular location: | |
Virion membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Host cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}. Secreted {ECO:0000305}. Note=Component of extracellular enveloped virus (EEV) but not intracellular mature virus (IMV). Anchored to the surface of the outermost membrane of EEV via its interaction with A56 protein. |
| Similarity: | |
Belongs to the receptors of complement activation (RCA) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.