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PDBsum entry 1vru
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Nucleotidyltransferase
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PDB id
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1vru
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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High resolution structures of HIV-1 rt from four rt-Inhibitor complexes.
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Authors
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J.Ren,
R.Esnouf,
E.Garman,
D.Somers,
C.Ross,
I.Kirby,
J.Keeling,
G.Darby,
Y.Jones,
D.Stuart.
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Ref.
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Nat Struct Biol, 1995,
2,
293-302.
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PubMed id
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Abstract
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We have determined the structures of four complexes of HIV-1 reverse
transcriptase with non-nucleoside inhibitors, three fully refined at high
resolution. The highest resolution structure is of the RT-nevirapine complex
which has an R-factor of 0.186 and a root-mean-square bond length deviation of
0.015 A for all data to 2.2 A. The structures reveal a common mode of binding
for these chemically diverse compounds. The common features of binding are
largely hydrophobic interactions and arise from induced shape complementarity
achieved by conformational rearrangement of the enzyme and
conformational/configurational rearrangement of the compounds.
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Secondary reference #1
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Title
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Mechanism of inhibition of HIV-1 reverse transcriptase by non-Nucleoside inhibitors.
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Authors
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R.Esnouf,
J.Ren,
C.Ross,
Y.Jones,
D.Stammers,
D.Stuart.
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Ref.
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Nat Struct Biol, 1995,
2,
303-308.
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PubMed id
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Secondary reference #2
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Title
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Crystals of HIV-1 reverse transcriptase diffracting to 2.2 a resolution.
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Authors
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D.K.Stammers,
D.O.Somers,
C.K.Ross,
I.Kirby,
P.H.Ray,
J.E.Wilson,
M.Norman,
J.S.Ren,
R.M.Esnouf,
E.F.Garman.
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Ref.
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J Mol Biol, 1994,
242,
586-588.
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PubMed id
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