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UniProt functional annotation for Q9WYV8 | ||
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| UniProt code: Q9WYV8. |
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| Organism: | |
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8). |
| Taxonomy: | |
Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga. |
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| Function: | |
Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. {ECO:0000305}. |
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| Catalytic activity: | |
Reaction=L-glutaminyl-[peptide chain release factor] + S-adenosyl-L- methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42896, Rhea:RHEA- COMP:10271, Rhea:RHEA-COMP:10272, ChEBI:CHEBI:15378, ChEBI:CHEBI:30011, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:61891; EC=2.1.1.297; |
| Subunit: | |
Monomer and homodimer. {ECO:0000269|PubMed:18247349, ECO:0000269|Ref.5}. |
| Miscellaneous: | |
The crystal structure corresponding to PDB 1SG9 shows a glutamate anhydride cross-link formed between the Glu-97 side chains from two molecules, but this has not been observed in other PrmC structures from T.maritima. This cross-link is suggested being an artifact of concentration during crystallization (PubMed:18247349). {ECO:0000305|PubMed:18247349}. |
| Similarity: | |
Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.