UniProt functional annotation for P42404

UniProt code: P42404.

Organism: Bacillus subtilis (strain 168).
Taxonomy: Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
 
Function: Catalyzes the isomerization between 3-hexulose 6-phosphate and fructose 6-phosphate. Together with HxlA, may act as a formaldehyde detoxification system.
 
Catalytic activity: Reaction=D-arabino-hex-3-ulose 6-phosphate = beta-D-fructose 6- phosphate; Xref=Rhea:RHEA:25900, ChEBI:CHEBI:57634, ChEBI:CHEBI:58542; EC=5.3.1.27;
Pathway: One-carbon metabolism; formaldehyde assimilation via RuMP pathway; D-fructose 6-phosphate from D-ribulose 5-phosphate and formaldehyde: step 2/2.
Subunit: Homotetramer. {ECO:0000269|PubMed:15363790}.
Induction: By formaldehyde, under the control of HxlR. Not induced by methanol, formate, or methylamine.
Similarity: Belongs to the SIS family. PHI subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.