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PDBsum entry 1vid

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Transferase (methyltransferase) PDB id
1vid
Jmol
Contents
Protein chain
213 a.a.
Ligands
SAM
DNC
Metals
_MG
Waters ×139

References listed in PDB file
Key reference
Title Crystal structure of catechol o-Methyltransferase.
Authors J.Vidgren, L.A.Svensson, A.Liljas.
Ref. Nature, 1994, 368, 354-358.
PubMed id 8127373
Abstract
Catechol O-methyltransferase (COMT, EC 2.1.1.6) is important in the central nervous system because it metabolizes catecholamine neurotransmitters such as dopamine. The enzyme catalyses the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to one hydroxyl group of catechols. COMT also inactivates catechol-type compounds such as L-DOPA. With selective inhibitors of COMT in combination with L-DOPA, a new principle has been realized in the therapy of Parkinson's disease. Here we solve the atomic structure of COMT to 2.0 A resolution, which provides new insights into the mechanism of the methyl transfer reaction. The co-enzyme-binding domain is strikingly similar to that of an AdoMet-dependent DNA methylase, indicating that all AdoMet methylases may have a common structure.
Secondary reference #1
Title Crystallization and preliminary X-Ray investigation of a recombinant form of rat catechol o-Methyltransferase.
Authors J.Vidgren, C.Tilgmann, K.Lundström, A.Liljas.
Ref. Proteins, 1991, 11, 233-236.
PubMed id 1749777
Abstract
PROCHECK
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 Headers