UniProt functional annotation for P51452

UniProt code: P51452.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. {ECO:0000269|PubMed:10224087, ECO:0000269|PubMed:11863439}.
 
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. {ECO:0000255|PROSITE-ProRule:PRU10044}.
Catalytic activity: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
Subunit: Interacts with VRK3, which seems to activate it's phosphatase activity. {ECO:0000250}.
Subcellular location: Nucleus {ECO:0000269|PubMed:10224087}.
Similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. {ECO:0000305}.
Similarity: Contains 1 tyrosine-protein phosphatase domain. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.