UniProt functional annotation for P19320

UniProt code: P19320.

Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Function:		Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha- 4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Subcellular location:		Membrane; Single-pass type I membrane protein.
Tissue specificity:		Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.
Induction:		By cytokines (e.g. IL-1, TNF-alpha).
Domain:		Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion.
Ptm:		Sialoglycoprotein.
Miscellaneous:		[Isoform 1]: Major isoform.

Annotations taken from UniProtKB at the EBI.