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UniProt functional annotation for Q5SHF5 | ||
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| UniProt code: Q5SHF5. |
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| Organism: | |
Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8). |
| Taxonomy: | |
Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus. |
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| Function: | |
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. {ECO:0000255|HAMAP-Rule:MF_00158}. |
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| Catalytic activity: | |
Reaction=(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+); Xref=Rhea:RHEA:10912, ChEBI:CHEBI:15378, ChEBI:CHEBI:15980, ChEBI:CHEBI:29032, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57966, ChEBI:CHEBI:456215; EC=6.3.2.1; Evidence={ECO:0000255|HAMAP-Rule:MF_00158}; |
| Pathway: | |
Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)- pantothenate from (R)-pantoate and beta-alanine: step 1/1. {ECO:0000255|HAMAP-Rule:MF_00158}. |
| Subunit: | |
Homodimer. {ECO:0000305|Ref.2}. |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00158}. |
| Miscellaneous: | |
The reaction proceeds by a bi uni uni bi ping pong mechanism. {ECO:0000255|HAMAP-Rule:MF_00158}. |
| Miscellaneous: | |
PDB 1UFV apparently has a Val-49-Ala mutation. |
| Similarity: | |
Belongs to the pantothenate synthetase family. {ECO:0000255|HAMAP-Rule:MF_00158}. |
Annotations taken from UniProtKB at the EBI.